Maryland raised roughly $2.4B across 250+ deals in 2025. Most capital went to life sciences and cybersecurity. The ecosystem is split between Baltimore's biotech corridor and the D.C. suburbs' federal contractor tech. You won't get far without understanding either Johns Hopkins research pipelines or government sales cycles.
New Enterprise Associates (Chevy Chase): Led Sparrow Pharmaceutics' $85M Series B, Baltimore's biggest biotech round in 2025
TEDCO: State-backed fund that invested in 13 Maryland companies in December 2025 alone
Grotech Ventures (Owings Mills): Backed Sturdy.ai at $6M seed and Base Operations at $9.1M Series A in 2025
ABS Capital (Baltimore): Led CERTIFY Health's Series A and Greenspace Health's Series B in 2025
Northpond Ventures (Bethesda): Multi-billion dollar life sciences fund with 4 Maryland deals in 2025
Maryland Venture Fund (Columbia): $110M evergreen fund investing $500K-$1.5M in Maryland tech companies
Camden Partners (Owings Mills): Growth equity firm that closed $100M sixth fund focused on software and tech-enabled services
Kinetic Ventures: Backed Protenus at $19M Series C in Baltimore's healthcare IT sector
Blu Venture Investors: Early investor in Mindgrub and multiple Baltimore B2B SaaS companies
JHU Technology Ventures: Johns Hopkins' investment arm spinning out university research with seed capital
Abell Foundation: Baltimore-focused foundation funding local companies with growth and social impact potential
Aldrich Capital Partners (Baltimore): Healthcare and life sciences investor backing companies with disruptive tech
Bonsal Capital: Mission-driven fund focused on edtech, healthcare, and cybersecurity solutions
TDF Ventures: Seed and Series A investor targeting Maryland tech companies
TCP Venture Capital (Baltimore): Early-stage tech fund with Baltimore-specific Propel Baltimore Fund
Maryland Momentum Fund: University System of Maryland's $16M fund for USM spinouts
Boulder Ventures: Early-stage fund backing Maryland tech companies since 1995
Early Charm Ventures (Baltimore): Builds companies from university IP in Pigtown neighborhood
Maryland has 40+ active funds but the ecosystem is bifurcated. Baltimore focuses on life sciences because of Johns Hopkins and NIH proximity. Average biotech Series A is $15-25M. The D.C. corridor (Bethesda, Chevy Chase, Rockville) funds cybersecurity and govtech because federal agencies are customers. Average B2B SaaS seed is $1-3M.
The state offers serious non-dilutive funding through SBIR/STTR matches. Maryland startups secured $28M+ in federal grants through TEDCO's proposal lab in 2024-2025. That's real money before you dilute. Most coastal VCs don't know about it.
Maryland investors move slower than SF but faster than Boston. Expect 4-6 meetings before term sheets. They're thorough with IP diligence if you're biotech. Software companies need government sales traction or enterprise contracts, not just MRR growth. Hopkins and University of Maryland spinouts get priority from local funds.
Geographic focus matters here. Baltimore investors prefer Baltimore companies for board meeting logistics. Bethesda funds will invest in Baltimore biotech but expect you to eventually relocate closer to NIH. If you're in Western Maryland or Eastern Shore, you'll need D.C. or Baltimore proximity or a remote-friendly fund.
Check their government relationships. Half of Maryland's tech economy depends on federal contracts. If you're selling to DoD, HHS, or intelligence agencies, your investor needs security clearances and procurement connections. Ask if they've helped portfolio companies navigate FedRAMP or SBIR Phase III transitions.
Life sciences investors expect IP. Baltimore biotech funds want patents or exclusive university licenses before Series A. The bar is higher than Boston or SF because Hopkins competition is fierce. Software investors want differentiated tech, not better UX on existing solutions.
Check sizes vary by geography. TEDCO does $500K-$1.5M. Maryland Venture Fund goes up to $750K initial checks. Grotech and ABS write $5-15M growth checks. NEA leads $20M+ rounds but doesn't lead many Maryland seeds. Know which stage you're actually ready for before reaching out.
Use Ellty to track opens. Maryland investors are polite but non-committal. Upload your deck and send trackable links. You'll see who actually reviewed your IP strategy versus who just skimmed the summary. Baltimore biotech investors spend 3x longer on patent slides than market size.
Follow-on capacity is limited. Most Maryland funds can't lead your Series B. Plan to bring in Boston or SF capital for growth rounds. Some founders raise seed locally, then relocate to Cambridge or Palo Alto. Others stay and build with customer revenue. Be honest about your path. Building a repeatable, compliant GDPR document sharing workflow builds trust before the first handshake.
Start with university connections. If you're a Hopkins, UMD, or UMBC spinout, go through the tech transfer office first. JHU Technology Ventures, UM Ventures, and Maryland Momentum Fund prioritize university deals. They'll intro you to other Maryland VCs if it's a fit.
Attend TEDCO events. Their Entrepreneur Expo, Builder Fund showcases, and SBIR proposal labs are where Maryland investors actually show up. These aren't networking happy hours. Come with traction or don't come at all.
Baltimore investors value local presence. If you're remote-first or planning to relocate to SF, say it upfront. Some will pass immediately. Others don't care but want honesty. Don't waste time pitching board seat value if you're moving in 12 months.
Track your outreach with Ellty. Create unique links for each Maryland investor. Baltimore VCs typically review decks within 48-72 hours if interested. If no activity after a week, they've passed. Don't follow up repeatedly. Move on to the next 10 funds.
Leverage SBIR/STTR grants. Apply through TEDCO's proposal lab before raising venture capital. Landing NIH or NSF Phase I proves federal agencies validated your tech. Maryland investors view this as de-risking. Upload grant docs to your Ellty data room before first meetings.
Join Baltimore innovation groups. ETC Baltimore, Emerging Technology Centers, and bwtech@UMBC are where Maryland founders actually meet investors. Skip the generic startup meetups. These workspaces host office hours with local VCs.
Reference Maryland exits. Mention Catalent's $1.2B acquisition of Paragon Bioservices or recent Hopkins spinout IPOs. Maryland investors funded those companies. Showing you understand the local success path matters more than citing SF unicorns.
Prepare for government talk. If you're B2B SaaS, expect questions about federal sales strategy. Can you get FedRAMP certified? Do you understand FAR clauses? Maryland investors pass on great products that can't navigate procurement. Set up an Ellty data room with your government partnerships and security compliance docs.
Maryland investors prefer profitable growth over blitzscaling. Burn $500K/month with no revenue path and you'll get ghosted. Baltimore and Bethesda VCs want 12-18 month runways and capital efficiency. It's a very different mentality from SF's growth-at-all-costs culture.
Biotech gets funded faster than SaaS in Maryland. If you're life sciences with Hopkins IP, you'll close rounds in 3-4 months. B2B SaaS without government traction takes 6-9 months. The capital concentration is clear. Plan your timeline accordingly.
One of the world's largest VCs with a Chevy Chase office that actively backs Maryland life sciences companies.
State-backed innovation agency with evergreen venture funds investing $500K-$1.5M in Maryland tech and life sciences companies.
Hunt Valley-based early-stage VC investing $500K-$5M in tech companies, particularly strong in B2B SaaS and enterprise software.
Baltimore growth equity firm with $2.5B+ invested since 1990, focusing on B2B software and tech-enabled services.
Multi-billion dollar science-driven VC with Bethesda office, one of the most active life sciences lead investors in the U.S.
$110M evergreen state fund investing directly in Maryland tech and life sciences companies since 1994.
Baltimore-based growth equity firm with 25+ years investing in software and tech-enabled business services.
Baltimore-based fund backing local healthcare IT and B2B SaaS companies with hands-on enterprise sales support.
Local fund focused on Maryland B2B software and services companies, early investor in Baltimore tech ecosystem.
Johns Hopkins' investment arm commercializing university research and providing early funding for Hopkins spinouts.
Baltimore-focused foundation investing in local companies with growth potential and social impact, especially workforce development.
Baltimore life sciences investor backing healthcare and biotech startups with disruptive technologies or novel business models.
Mission-driven partnership investing in tech-enabled services in education, healthcare, and cybersecurity since 1999.
D.C.-based VC targeting seed and Series A investments in Maryland and surrounding region technology companies.
Baltimore early-stage tech VC with Propel Baltimore Fund specifically for companies locating in Baltimore.
University System of Maryland's $16M fund providing $150K-$500K investments in USM spinouts from 12 institutions.
Early-stage venture firm investing in market-leading technology companies since 1995, active in Maryland deals.
Baltimore-based firm licensing university IP and manufacturing products in Pigtown, focused on sustainable value creation.
These 18 investors closed Maryland deals in 2025-2026. Before you start reaching out to Baltimore, Bethesda, or Columbia funds, set up proper tracking.
Upload your deck to Ellty and create a unique link for each Maryland investor. You'll see exactly which slides they view and how long they spend on your IP portfolio or government contracts section. Maryland-based founders often find biotech investors skip market size but focus heavily on patent protection and regulatory pathways, while B2B SaaS investors want federal sales pipeline details.
When Maryland investors ask for more materials, share an Ellty data room instead of messy email threads. Your licensing agreements, SBIR documentation, Hopkins collaboration agreements, and federal contracts in one secure place with view analytics.
Do I need to be based in Maryland to raise from Maryland investors?
Most Maryland funds prefer local companies for board meeting logistics, especially Baltimore investors. If you're a Hopkins or UMD spinout, you'll get meetings regardless of location. Remote-first companies should target growth-stage funds like NEA or ABS that don't require local presence. Be upfront about relocation plans.
How does Maryland compare to Boston or SF for fundraising?
Maryland has less capital but stronger government and life sciences advantages. If you're selling to federal agencies or spinning out of Hopkins, Maryland is better than SF. For consumer or general B2B SaaS, Boston or SF have 10x more investors. Maryland VCs prefer profitable growth over blitzscaling.
What's the average seed round size in Maryland?
$1-3M for B2B SaaS, $3-8M for life sciences. TEDCO and Maryland Venture Fund write $500K-$1.5M checks. Grotech and local VCs do $2-5M. If you need $5M+ seed rounds, you'll need to bring in D.C. or Northeast funds alongside local investors.
Should I raise locally or go straight to SF/NYC?
Raise locally if you're Hopkins/UMD spinout, selling to federal government, or building capital-efficient B2B business. Go to SF/NYC if you're consumer, need $10M+ seed, or want fast follower rounds. Many Maryland founders do seed locally, then Series A in Boston with Maryland VCs participating.
Do Maryland investors expect in-person meetings?
Baltimore investors strongly prefer in-person for first meetings. Bethesda and Chevy Chase funds are more flexible with video. Once you're in diligence, expect to visit their offices multiple times. COVID changed some of this but Maryland is more traditional than SF.
What industries get funded most in Maryland?
Life sciences and biotechnology dominate because of Hopkins, NIH, and FDA proximity. Cybersecurity and govtech get significant capital due to federal contractors. B2B SaaS with government sales potential. Healthcare IT. Materials science and advanced manufacturing from university research. Consumer and fintech get minimal Maryland funding.
How important are SBIR/STTR grants for Maryland fundraising?
Extremely important. Maryland has the best SBIR infrastructure in the country through TEDCO's proposal lab. Landing Phase I proves government validation. Local VCs view federal grants as de-risking. Many Maryland biotech companies stack $2-3M in SBIR funding before raising institutional capital, which improves valuations significantly.